HMOX1 anticorps (AA 150-286)

N° du produit ABIN968130

Cet anticorps anti-HMOX1 est un anticorps Souris Monoclonal détectant HMOX1 dans WB, IHC, IP et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour HMOX1 anticorps (AA 150-286) (ABIN968130)

Antigène: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HMOX1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: 23-Heme Oxygenase 1

Détail du produit anti-HMOX1 anticorps

Épitope: AA 150-286

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Heme Oxygenase 1 (HO-1) aa. 150-286

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-HMOX1 (ABIN968130)

Suzuki, Ishizaka, Tsukamoto, Minami, Taguchi, Nagai, Ohno: "Pressurization facilitates adenovirus-mediated gene transfer into vein graft." dans: FEBS letters, Vol. 470, Issue 3, pp. 370-4, (2000) (PubMed).

Foresti, Clark, Green, Motterlini: "Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions." dans: The Journal of biological chemistry, Vol. 272, Issue 29, pp. 18411-7, (1997) (PubMed).

Ishikawa, Navab, Leitinger, Fogelman, Lusis: "Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL." dans: The Journal of clinical investigation, Vol. 100, Issue 5, pp. 1209-16, (1997) (PubMed).

Yoshida, Biro, Cohen, Müller, Shibahara: "Human heme oxygenase cDNA and induction of its mRNA by hemin." dans: European journal of biochemistry / FEBS, Vol. 171, Issue 3, pp. 457-61, (1988) (PubMed).

Détails sur HMOX1

Antigène: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Autre désignation: Heme Oxygenase 1

Sujet: Heme oxygenases 1 and 2 (HO-1, HO-2) cleave the heme molecule, resulting in the production of carbon monoxide (CO) and biliverdin. HO-1 is a 288 amino acid monooxygenase with a molecular weight of 32 kDa. While HO-2 is constitutively expressed in tissues, HO-1 is rapidly induced by several stimuli such as lutathione depletion, hemin, heat shock, heavy metals, oxidative stress, oxidized LDL, anoxia, and endotoxic shock. Similar to nitric oxide (NO), CO activates guanylate cyclase and reduces platelet aggregation. Several conditions that increase NO also induce HO-1 expression and activity. This suggests that NO synthases, Cox-2, and HO-1 are part of a general defense mechanism against stress and pathogen invasion.

Poids moléculaire: 32 kDa

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interactome